Labial melanotic macule Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after Oral pathology: Noting a pigmented macule that often presents a diagnostic dilemma Registered Dental Hygienists Figure 7 from Pigmented lesions of the oral mucosa and perioral tissues: a flow chart for the diagnosis and some recommendations for the management. Semantic Scholar Labial lentigines, also called labial melanotic macules, is a benign skin condition that is more common in individuals with darker skin. They most often appear during adulthood although they can develop at Oral Melanotic Macule: Symptoms and Treatment Skinsight