Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature, and immunohistochemical analysis Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Frontiers Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Consultant360 Oral Melanotic Macule: Symptoms and Treatment Skinsight Lingual melanotic macule the first case report in an adult patient* Anais Brasileiros de Dermatologia