For 20 years, it seemed "obvious" that NSAIDs blunt training adaptation. Trappe 2002 showed ibuprofen suppressed muscle protein synthesis 24 hours after exercise. Mikkelsen 2009 showed a local NSAID infusion blocked satellite Common Adverse Events and Interactions with OTC Pain Medications Synthesis of Ibuprofen Conjugated Molecular Transporter Capable of Enhanced Brain Penetration Biswas 2017 Journal of Chemistry Wiley Online Library Ibuprofen administration attenuates serum TNF levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation ScienceDirect Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Alanine and glutathione targeting of dopamine or ibuprofen coupled polypeptide nanocarriers increases both crossing and protective effects on a bloodbrain barrier model Fluids and Barriers of the CNS Springer Nature Link