Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. PGC 1 Induces Susceptibility To Acetaminophen Driven Acute Liver Failure Scientific Reports Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect