Leucovorin (Folinic Acid) The Rescue Drug! Pearl:Leucovorin (Folinic Acid) is Methotrexate's antidote. It is the reduced form of folate that can bypass the enzyme dihydrofolate reductase (which Methotrexate inhibits). Application: It Epicatechin ameliorative effects on methotrexate induced hepatotoxicity in mice Reza Azadnasab, Hadi Kalantar, Layasadat Khorsandi, Heibatullah Kalantari, Mohammad Javad Khodayar, 2021 Busting the myth of methotrexate chronic hepatotoxicity Nature Reviews Rheumatology Mitochondrial glutathione redox cycle and interaction with other antioxidant MedLink Neurology Whey protein concentrate ameliorates the methotrexate induced liver and kidney damage British Journal of Nutrition Cambridge Core Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference? ScienceDirect