Are Freckles on Lips a Cause for Concern? Causes, Remedies Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Clinical Challenge: Dark Lesion on Lower Lip MPR A collection of resources for RACGP exams Next Gen GP Text Book live webinars AKT and KFP questions Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after